Trimox Effects, Warnings, Precautions, Countraindications

Warnings and Cautions

Do not use Trimox if:

  • you are allergic to any ingredient in Trimox penicillin or antibiotics (for example, ampicillin),
  • have recently received or will receive the live oral typhoid vaccine

Contact your doctor or healthcare provider immediately if you experience any of these situations.

Some medical conditions can interact with Trimox. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following:

  • if you are pregnant, plan to become pregnant, or are breastfeeding
  • if you are taking any prescription or over-the-counter medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods or other substances
  • if you have a history of allergies, asthma, hay fever, or hives
  • if you have had a severe allergic reaction (eg, skin rash, hives, breathing difficulties, dizziness) to a cephalosporin (eg, cephalexin), or to other beta-lactam antibiotics (eg, imipenem)
  • if you have kidney problems, gonorrhea or infectious mononucleosis (mono)


Some drugs may interact with Trimox. Tell your doctor if you are taking any other medications, especially any of the following:

  • Blood thinners (such as warfarin), because the risk of bleeding may be higher
  • Probenecid, as it can increase the amount of Trimox in the blood
  • Chloramphenicol, macrolide antibiotics (eg, erythromycin), sulfonamides (eg, sulfamethoxazole), or tetracycline antibiotics (eg, doxycycline), as they may decrease Trimox’s effectiveness of Methotrexate, due to the risks of its side effects can increase Trimox
  • Provigil (Modafinil) for depression treatment
  • Live oral typhoid vaccine or hormonal contraceptives (for example, birth control pills), as their effectiveness may be reduced by Trimox

Possible side effects

All medications can cause side effects, but many people have no, or fewer, side effects. Check with your doctor if any of these more common side effects persist or become bothersome:

  • Diarrhea, nausea, vomiting.

Seek medical attention immediately if any of these serious side effects occur:

Serious allergic reactions (skin rash, hives, itching, difficulty breathing, tightness in the chest, swelling of the mouth, face, lips or tongue), bloody stools, confusion, dark urine, fever, chills or persistent sore throat , red, swelling of the skin, blistering or peeling, seizures, severe diarrhea, stomach pain or cramps, unusual bleeding or bruising, vaginal discharge or irritation, yellowing of the skin or eyes.